NFL Injury Report Friday Updates: Game-Time Decisions for Murray and Johnston?

Injury hotspots for Week 6 include Seattle's secondary, the Chargers' offensive line, New England's secondary, Tampa Bay's receiving corps, the Cowboys' entire roster, Detroit's secondary and Green Bay's offensive line.

Below you'll find four different categories, with our lists including key offensive linemen and defensive players whose absences might impact fantasy decisions. The bottom section, for potential game-day decisions, is sorted by kickoff times. It can be used as a checklist/cheatsheet for Sunday morning and afternoon when inactives come out and we need to adjust lineups. Before we get to the 'questionable' players, let's see who's definitely in and who's definitely out...

Good to Go 💯

• RB Tyjae Spears (ankle)
• RB Bhayshul Tuten (shoulder)
• RB Kyle Monangai (thigh)
• WR Xavier Worthy (shoulder/ankle)
• WR Amon-Ra St. Brown (wrist)
• WR Alec Pierce (concussion)
• WR Dyami Brown (shoulder)
• TE Darren Waller (hip)
• TE Juwan Johnson (ankle)
• TE Tyler Higbee (hip)
• TE Michael Mayer (concussion)

Ruled Out/Doubtful 🚑 

Out/Doubtful/IR

• QB Lamar Jackson (hamstring)
• QB Brock Purdy (toe)
• RB Chuba Hubbard (calf)
• RBs Bucky Irving (shoulder/ankle) & Josh Williams (concussion)
• RB Antonio Gibson (knee - out for season)
• RB Miles Sanders (knee - out for season)
• RB Tyler Goodson (groin)
• WRs CeeDee Lamb (ankle) & KaVontae Turpin (foot)
• WRs Mike Evans (hamstring) & Chris Godwin (fibula)
• WR Ricky Pearsall (knee)
• WR Calvin Austin (shoulder)
• WR Christian Watson (IR - knee)
• WR Allen Lazard (personal)
• TE Brock Bowers (knee)
• TE Brenton Strange (quad - out 5+ weeks)
• K Joey Slye (calf)

Potential Workload Beneficiaries (From Injuries Above)

• QB Cooper Rush
• QB Mac Jones (knee/oblique)
• RBs Rico Dowdle, Trevor Etienne & DeeJay Dallas
• RBs Rachaad White & Sean Tucker
• RBs Rhamondre Stevenson & TreVeyon Henderson
• WRs Jalen Tolbert & Ryan Flournoy
• WRs Sterling Shepard & Tez Johnson
• WRs Kendrick Bourne & Demarcus Robinson
• WRs Roman Wilson, Scotty Miller & Ben Skowronek
• TE Michael Mayer
• TE Hunter Long
• K Matthew Wright

Key Defensive Players + Offensive Linemen

• CB Devon Witherspoon (knee), CB Riq Woolen (head), S Julian Love (hamstring)
• CB Kenny Moore (Achilles)
• LB Tyrel Dodson (concussion)
• S Jaylinn Hawkins (hamstring)
• DT Devonte Wyatt (knee)
• CB Terrion Arnold (shoulder)
• LB Jonah Elliss (ribs)
• LB Omar Speights (high ankle) 
• LB Jonah Elliss (ribs) + G Ben Powers (biceps)
• LB Roquan Smith (hamstring) + FB Patrick Ricard (calf) + CB Chidobe Awuzie (hamstring)
• G Tyler Booker (ankle) + LB Jack Sanborn (head)
• C Robert Hainsey (D - hamstring)
• RT Taylor Moton (elbow)
• LT Joe Alt (ankle) + RT Trey Pipkins (knee)

Listed as Questionable - Should Play 👍

• QB Mac Jones (oblique/knee)
• WR Van Jefferson (ankle)
• WR Deebo Samuel (calf)
• TE Colby Parkinson (concussion)

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Truly Questionable / Game-Time Decisions 🤔

Early Games

• QB Kyler Murray (toe)
• RB Alvin Kamara (ankle)
• WR Zay Flowers (shoulder)
• WR Quentin Johnston (hamstring)
• WR Tutu Atwell (hamstring)
• WR Jonathan Mingo (IR - knee)
• WR Zay Jones (knee)
• WR Jalen Coker (IR - quad) & TE Ja'Tavion Sanders (ankle)

Flowers seems likely to play, while Murray, Kamara and Johnston are more up in the air. All were limited practice participants Friday, potentially setting up game-day decision heading into the weekend. Early kickoffs are good news for fantasy managers.

Late-Afternoon Games

• WR Jauan Jennings (ankle/rib)
• WR Ja'Marr Chase (illness)
• K Brandon McManus (leg)

All three of these guys seem more likely than not to play. If not, Kendrick Bourne and Tee Higgins would be the No. 1 receivers for their respective teams, catching passes from Mac Jones and Joe Flacco.

Primetime Games

• WR Kalif Raymond (neck) - SNF 
• TE Dalton Kincaid (oblique) + WR Curtis Samuel (neck/ribs) - MNF 7:15 ET
• WR Darnell Mooney (hamstring) - MNF 7:15 ET
• WRs Terry McLaurin (quad) & Noah Brown (knee) - MNF 8:15 ET
• RB Chris Rodriguez (calf) - MNF 8:15 ET
• TE Colston Loveland (hip) - MNF 8:15 ET

It isn't looking good for Mooney, McLaurin and Rodriguez, all listed as 'DNP' both Thursday and Friday. The others here all managed varying levels of practice participation. Kincaid seems on track to play.

Key Defensive Players + O-Linemen

• CB Christian Gonzalez (hamstring)
• CB Max Melton (hamstring) + LB Mack Wilson (ankle)
• CB DaRon Bland (shoulder) + CB Trevon Diggs (knee) + G Tyler Smith (knee)
• CB Jalen Ramsey (hamstring
• CB A.J. Terrell (hamstring)
• S Brian Branch (ankle), S Kerby Joseph (knee), CB Avonte Maddox (hamstring)
• T Taylor Decker (shoulder)
• G Aaron Banks (groin), T Zach Tom (oblique), T Rasheed Walker (quad)
• C Aaron Brewer (pectoral) + CB Storm Duck (ankle) 
• DT Grady Jarrett (knee) + CB Kyler Gordon (hamstring) + RT Darnell Wright (elbow)
• DT Ed Oliver (ankle) + LB Matt Milano (pec)