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Audric Estime
Chances of lead role rising
Estime and Evan Hull will likely be the only healthy running back options for the Saints in Week 16 against the Jets, as Alvin Kamara didn't practice Thursday, while Devin Neal was placed on injured reserve Thursday.
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De'Von Achane
Upheaval at QB
Achane will have Quinn Ewers as his quarterback in Week 16 against the Bengals, as Ian Rapoport of NFL Network reports that the Dolphins have decided to bench Tua Tagovailoa in favor of Ewers.
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Jeremiyah Love
Ready to join NFL ranks
Love has declared for the 2026 NFL Draft and is expected to be the first running back drafted, per Pete Thamel of ESPN.com.
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Michael Carter
Back atop backfield depth chart
Carter is likely to work as Arizona's lead back down the stretch, as Zach Gershman of the team's official site reports that Bam Knight was placed on injured reserve Tuesday due to an ankle injury.
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Javonte Williams
Pushing Dallas into tough decision
The Cowboys will have a tough decision to make regarding Williams' future with the team this offseason, Todd Archer of ESPN reports.
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Evan Hull
Role could grow after Neal injury
Hull could play a large role in New Orleans' backfield in Week 16 against the Jets, as Devin Neal suffered a hamstring injury during the Week 15 win over the Panthers.
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Audric Estime
Could have larger role in Week 16
Estime could lead New Orleans' backfield in Week 16 against the Jets, as Devin Neal suffered a hamstring injury during the Week 15 win over the Panthers.
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Jacory Croskey-Merritt
Could have expanded Week 15 role
Croskey-Merritt could see more opportunities in Week 15 against the Giants, as Adam Schefter of ESPN reports that Chris Rodriguez will be a game-time decision due to a groin injury.
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Josh Jacobs
Expected to play in Week 15
Jacobs is expected to play through his knee injury in Week 15 against the Broncos, per Adam Schefter of ESPN.
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Christian McCaffrey
Close to yardage milestone
McCaffrey needs just 145 more yards from scrimmage to reach the 1,800-yard mark for the fifth time in his NFL career, per NFL.com.
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Jahmyr Gibbs
Close to surpassing TD record
Gibbs has 47 receiving or rushing touchdowns since entering the league in 2023, and with one more score, he would surpass Hall of Fame running back Barry Sanders for the most touchdowns by a player both in their first three career seasons and before their 24th birthday, per NFL.com.
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Emanuel Wilson
Could get more Week 15 carries
Wilson could see an expanded workload Sunday against the Broncos, as Matt Schneidman of The Athletic reports that Josh Jacobs didn't practice Thursday and is day-to-day due to a knee injury.
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Bam Knight
Likely lead back for rest of 2025
Knight is poised to operate as the top option in Arizona's backfield on early downs for the remainder of the 2025 season, as Darren Urban of the Cardinals' official site reports that Trey Benson will spend the remainder of the 2025 season on injured reserve due to a knee injury.
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Trey Benson
Done for 2025 campaign
Head coach Jonathan Gannon revealed Wednesday that Benson will spend the remainder of the 2025 season on injured reserve due to a knee injury, per Darren Urban of the Cardinals' official site.
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Dare Ogunbowale
Could have bigger role in Week 15
Ogunbowale could be in line for a larger role in Week 15 against the Cardinals, as Woody Marks and Nick Chubb were both sidelined at Wednesday's practice.
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Keaton Mitchell
Drew interest at trade deadline
Mitchell was the subject of trade inquiries from multiple teams at the trade deadline, but the Ravens rebuffed the offers, Mike Garafolo of NFL Network reports.
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De'Von Achane
May not miss time
Achane doesn't believe he'll miss any time as a result of the rib injury he suffered in Sunday's win over the Jets, Cameron Wolfe of NFL Network reports.
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Jaylen Wright
Could have expanded role in Week 15
Wright could take on a larger workload in Week 15 against the Steelers, as De'Von Achane exited the Week 14 win over the Jets due to a rib injury.
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Tony Pollard
Facing tough Browns run defense
Pollard is in for a tough battle Sunday against a Browns run defense that allows a league-best 31 percent success rate on opposing runs, Seth Walder of ESPN reports.
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Bam Knight
Possible elevated receiving role
Knight could be in for extra pass-catching work out of the backfield in Sunday's game against the Rams due to the Cardinals being down two wide receivers, per Josh Weinfuss of ESPN.com.
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Breece Hall
Chance for first 1,000-yard season
Hall needs 166 rushing yards over the Jets' final five games of the 2025 regular season to become the team's first 1,000-yard rusher since Chris Ivory in 2015, per Rich Cimini of ESPN.com.
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Kyren Williams
Likely to play through ankle issue
Head coach Sean McVay said Wednesday that he expects Williams to play Sunday against the Cardinals, per Adam Grosbard of The Orange County Register.
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Kimani Vidal
Likely to be joined by Hampton soon
Head coach Jim Harbaugh said Wednesday that Omarion Hampton is "on track and looking good" for a Week 14 return against the Eagles, per Eric Smith of the Chargers' official site, so Vidal's time as the lead back is likely coming to a close.
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Omarion Hampton
On track for Week 14
Head coach Jim Harbaugh said Wednesday that Hampton is "on track and looking good" for a Week 14 return against the Eagles, though Harbaugh said the team still wants to see how the week of practice unfolds regarding Hampton's ankle injury, Eric Smith of the Chargers' official site reports.
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Devin Neal
In line for second straight start
Neal is likely to make a second consecutive start in Week 14 against the Buccaneers, as Alvin Kamara didn't practice Thursday due to knee and ankle injuries.
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