San Francisco 49ers Odds For 2025 | +2000 Super Bowl Odds

OG

Connor Colby: Will start for SF on Sunday

Sep 21st

Colby (groin) is active for Sunday's Week 3 clash against the Cardinals, Briana Jeannel of the 49ers' official site reports.

RB

Jordan James: Won't play against Arizona

Sep 21st

James (coach's decision) is inactive for Sunday's game against the Cardinals, Briana Jeannel of the 49ers' official site reports.

QB

Mac Jones: Another spot start in place of Purdy

Sep 21st

Jones will start Sunday's game against the Cardinals after the 49ers ruled out Brock Purdy (left shoulder/toe).

QB

Brock Purdy: Officially out for Week 3

Sep 21st

The 49ers downgraded Purdy (toe/shoulder) from questionable to out for Sunday's game against the Cardinals.

WR

Jauan Jennings: Downgraded to out for Week 3

Sep 21st

The 49ers downgraded Jennings (ankle/shoulder) from questionable to out for Sunday's game against the Cardinals.

WR

Kendrick Bourne: Should see uptick in snaps Sunday

Sep 21st

San Francisco head coach Kyle Shanahan said that Bourne is "probably" going to be a starting receiver for the team in Sunday's game against the Cardinals with Jauan Jennings (ankle) listed as questionable but set to be inactive for the Week 3 contest, Matt Maiocco of NBC Sports Bay Area reports.

WR

Jauan Jennings: Not on track to play Sunday

Sep 21st

Jennings (ankle/shoulder) is not in line to play Sunday against the Cardinals, according to Adam Schefter of ESPN.

QB

Brock Purdy: In line to sit Sunday

Sep 21st

Purdy (left shoulder/toe) isn't in line to play Sunday against the Cardinals, Adam Schefter of ESPN reports.

QB

Brock Purdy: Could return to lineup in Week 4

Sep 21st

The 49ers are optimistic that Purdy (toe/shoulder) -- who is listed as questionable but not expected to play Sunday against the Cardinals -- could be ready to start the team's Week 4 game versus the Jaguars, Ian Rapoport of NFL Network reports.

OG

Spencer Burford: Lands on IR

Sep 20th

Burford (knee) was placed on injured reserve Saturday.