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Browns vs Bills Odds, Lines, Spreads & Totals 2025

Bills
26.3 Pts
Browns
16.3 Pts
Sunday December 21, 2025 at 1:00 PM ET
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BUF
Bills Injury Report
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CLE
Browns Injury Report
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BUF
Bills Lineup
Inactives
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CLE
Browns Lineup
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BUF
Bills News
#8 WR
Mecole Hardman: Nearing return to practice
Dec 15th
Bills head coach Sean McDermott said Monday that Hardman (calf) could have his 21-day practice window opened this week, Chris Brown of the Bills Radio Network reports.
#2 DT2
Jordan Phillips: Already ruled out for Week 16
Dec 15th
Head coach Sean McDermott said that Phillips won't play Sunday against the Browns due to an ankle injury he suffered in the team's Week 15 win over the Patriots, Alec White of the Bills' official site reports.
#1 K
Matt Prater: Out for Week 16
Dec 15th
Bills head coach Sean McDermott said that Prater has been ruled out for Sunday's game against the Browns due to a right quadriceps injury, Jay Skurski of The Buffalo News reports.
#5 WR
Brandin Cooks: No catches vs. New England
Dec 15th
Cooks (undisclosed) failed to catch any of his three targets during Sunday's 35-31 win over the Patriots.
#4 WR
Tyrell Shavers: Blanks Sunday
Dec 15th
Shavers played 34 of the Bills' 67 offensive snaps but wasn't targeted during Sunday's 35-31 win over the Patriots.
#2 RB
Ray Davis: Excels as kick returner in Week 15
Dec 15th
Davis caught his lone target for 13 yards and returned four kickoffs for 164 yards during Sunday's 35-31 win over the Patriots.
#1 TE
Dalton Kincaid: Modest numbers in win
Dec 14th
Kincaid secured three of four targets for 34 yards in the Bills' 35-31 win over the Patriots on Sunday.
#2 WR
Joshua Palmer: One catch in victory
Dec 14th
Palmer caught one of two targets for 16 yards in Sunday's 35-31 win over the Patriots.
#2 TE
Dawson Knox: Pair of TD grabs in win
Dec 14th
Knox secured three of four targets for 37 yards and two touchdowns in the Bills' 35-31 win over the Patriots on Sunday.
#3 RB
Ty Johnson: Gets seven touches in Week 15 win
Dec 14th
Johnson turned four carries into 13 yards and caught three passes on as many targets for 15 yards during the Bills' 35-31 win over the Patriots on Sunday.
#1 WR
Khalil Shakir: Leads Bills pass catchers in win
Dec 14th
Shakir secured all five targets for 65 yards in the Bills' 35-31 win over the Patriots on Sunday.
#1 RB
James Cook: Three-TD day against tough defense
Dec 14th
Cook rushed 22 times for 107 yards and two touchdowns while bringing in two of three targets for four yards and another score in the Bills' 35-31 win over the Patriots on Sunday.
#1 QB
Josh Allen: Leads furious comeback Sunday
Dec 14th
Allen completed 19 of 28 passes for 193 yards with three touchdowns and no interceptions and rushed 11 times for 48 yards in the Bills' 35-31 win over the Patriots on Sunday.
#1 RCB
Christian Benford: Unable to suit up Week 15
Dec 14th
Benford (toe) is inactive for Sunday's tilt versus the Patriots.
#1 MLB
Terrel Bernard: Not ready to return Week 15
Dec 14th
Bernard (elbow) is inactive for Sunday's clash against New England.
#6 WR
Gabe Davis: Inactive Sunday
Dec 14th
Davis is inactive for Sunday's game against the Patriots.
#2 RCB
Maxwell Hairston: Getting start Sunday
Dec 14th
Hairston will be one of Buffalo's starting cornerbacks in Week 15 versus New England as a result of Christian Benford missing the game due to a toe injury, Cameron Wolfe of NFL Network reports.
#1 RT
Spencer Brown: Set to start Sunday
Dec 12th
Brown (shoulder) doesn't have an injury designation ahead of Sunday's game against the Patriots.
#1 RDE
Joey Bosa: Ready to face Pats
Dec 12th
Bosa (hamstring/wrist) does not carry an injury designation for Sunday's game against New England.
#2 QB
Mitchell Trubisky: All clear for Week 15
Dec 12th
Trubisky (illness) does not carry an injury designation for Sunday's game against the Patriots.
#1 FS
Cole Bishop: Recovered from calf cramps
Dec 10th
Bishop (calf) was a full participant in Wednesday's walk-through practice, Bills Radio Broadcaster Chris Brown reports.
#3 TE
Jackson Hawes: Catches clutch touchdown pass
Dec 8th
Hawes caught a three-yard touchdown pass during the Bills' 39-34 win over the Bengals on Sunday.
#3 WR
Keon Coleman: Manages two catches against Bengals
Dec 7th
Coleman logged two receptions on three targets for 16 yards Sunday in a 39-34 Week 14 win over Cincinnati.
#4 LDT
Ed Oliver: Playoff return still possible
Dec 7th
Head coach Sean McDermott reiterated Friday that Oliver, who's on injured reserve with a biceps injury, could return to practice if Buffalo makes the playoffs, the Maddy Glab of the Bills' official site reports. "There's a chance. it would be more after the regular season, if we can get that far," McDermott said. "So that's kind of where his window would open up."
#1 LT
Dion Dawkins: Clears concussion protocol
Dec 5th
Dawkins has cleared the league's concussion protocol and will be available for Sunday's game against the Bengals, Katherine Fitzgerald of The Buffalo News reports.
#3 SS
Darnell Savage: Scooped up by Buffalo
Dec 5th
The Bills claimed Savage off waivers from the Commanders on Friday.
#2 LDE
A.J. Epenesa: Past foot injury
Dec 5th
Epenesa (foot) has no injury designation ahead of Sunday's matchup against the Bengals.
CLE
Browns News
#1 MLB
Carson Schwesinger: Logs another big tackle total
Dec 15th
Schwesinger notched 14 tackles (four solo) in Sunday's blowout loss to the Bears.
#1 RDE
Myles Garrett: Inches closer to sacks record
Dec 15th
Garrett logged four tackles, including 1.5 sacks, in a Week 15 loss to Chicago.
#6 WR
Jamari Thrash: Returns to Cleveland
Dec 15th
Thrash signed with the Browns on Monday.
#2 WR
Cedric Tillman: Limited snap count in loss
Dec 15th
Tillman was not targeted over seven snaps in Sunday's 31-3 loss to Chicago in Week 15.
#4 WR
Gage Larvadain: Season-high snap count
Dec 15th
Larvadain caught one of two targets for eight yards and returned one punt for one yard in Sunday's 31-3 loss to the Bears in Week 15.
#5 WR
Malachi Corley: Targeted once in loss
Dec 15th
Corley caught his lone target for 10 yards and returned two kickoffs for 45 yards in Sunday's 31-3 loss to Chicago in Week 15.
#4 RB
Raheim Sanders: Activated but does not play
Dec 15th
Sanders was added to the active roster but did not play in Sunday's 31-3 loss to the Bears in Week 15.
#3 RB
Trayveon Williams: Debuts for Cleveland
Dec 15th
Williams had one carry for three yards and caught both of his targets for four yards in Sunday's 31-3 loss to Chicago in Week 15. He also returned two kickoffs for 41 yards.
#1 K
Andre Szmyt: One kick in defeat
Dec 14th
Szmyt made his only field-goal attempt in Sunday's 31-3 loss to the Bears.
#3 WR
Isaiah Bond: Two long catches
Dec 14th
Bond recorded two receptions on four targets for 89 yards in Sunday's 31-3 loss to the Bears.
#1 TE
Harold Fannin: Targeted 14 times
Dec 14th
Fannin recorded seven receptions on 14 targets for 48 yards in Sunday's 31-1 loss to the Bears. He added one rush for two yards.
#1 WR
Jerry Jeudy: Held in check in Week 15
Dec 14th
Jeudy caught two of four targets for 22 yards in Sunday's 31-3 loss to the Bears.
#1 RB
Quinshon Judkins: Shut down by Bears
Dec 14th
Judkins rushed the ball 12 times for 21 yards in Sunday's 31-3 loss to the Bears. He added three receptions on four targets for minus-4 yards.
#1 QB
Shedeur Sanders: Hype slows in blowout loss
Dec 14th
Sanders completed 18 of 35 passes for 177 yards, no touchdowns and three interceptions in Sunday's 31-3 loss to the Bears. He added two rushes for 24 yards.
#2 LG
Teven Jenkins: Won't return due to shoulder injury
Dec 14th
Jenkins (shoulder) has been ruled out for the rest of Sunday's game against the Bears, Patrick Finley of the Chicago Sun-Times reports.
#2 RG
Teven Jenkins: Won't return due to shoulder injury
Dec 14th
Jenkins (shoulder) has been ruled out for the rest of Sunday's game against the Bears, Patrick Finley of the Chicago Sun-Times reports.
#1 DT2
Mason Graham: Active for Week 15
Dec 14th
Graham (ribs) is active for Sunday's game against Chicago.
#1 LG
Joel Bitonio: Able to play Sunday
Dec 14th
Bitonio (knee/back) is active for Sunday's battle against the Bears.
#3 RG
Zak Zinter: Won't play Week 15
Dec 13th
Zinter (back) has been ruled out for Sunday's matchup versus the Bears.
#2 C
Garrett Dellinger: Joins active roster
Dec 13th
The Browns signed Dellinger to their active roster Saturday.
#1 RT
Jack Conklin: Remaining in concussion protocol
Dec 12th
Conklin (concussion) has been ruled out for Sunday's game against Chicago, Mary Kay Cabot of The Cleveland Plain Dealer reports.
#1 RG
Wyatt Teller: Ruled out Week 15
Dec 12th
Teller (calf) has been ruled out for Sunday's game against the Bears, Mary Kay Cabot of The Cleveland Plain Dealer reports.
#3 DT2
Adin Huntington: Not playing Week 15
Dec 12th
Huntington (quadriceps) has been ruled out for Sunday's game against the Bears, Mary Kay Cabot of The Cleveland Plain Dealer reports.
#1 LDT
Shelby Harris: Ready to go Sunday
Dec 12th
Harris (knee) has no injury designation ahead of Sunday's matchup against the Bears, Scott Petrak of the Elyria Chronicle-Telegram reports.
#1 SS
Grant Delpit: Ready to play Sunday
Dec 12th
Delpit (illness/groin) has no injury designation ahead of Sunday's matchup against the Bears, Scott Petrak of the Elyria Chronicle-Telegram reports.
#4 TE
Brenden Bates: Ready to go Sunday
Dec 12th
Bates (ankle) has no injury designation ahead of Sunday's matchup against the Bears, Scott Petrak of the Elyria Chronicle-Telegram reports.
#1 LCB
Denzel Ward: Out for Week 15
Dec 12th
Ward (calf) has been ruled out ahead of Sunday's matchup against the Bears, Mary Kay Cabot of The Cleveland Plain Dealer reports.
#2 TE
David Njoku: Won't play Sunday
Dec 12th
Njoku (knee) has been ruled out for Sunday's game against the Bears, Mary Kay Cabot of The Cleveland Plain Dealer reports.
#2 RB
Dylan Sampson: Ruled out for Week 15
Dec 12th
Sampson (calf/hand) has been ruled out for Sunday's game against the Bears, Scott Petrak of the Elyria Chronicle-Telegram reports.
#1 FS
Ronnie Hickman: Logs four tackles vs. Tennessee
Dec 9th
Hickman logged four tackles (three solo) during the Browns' 31-29 loss to the Titans on Sunday.
#1 SLB
Devin Bush: Excels despite loss in Week 14
Dec 9th
Bush notched nine tackles (three solo) and two defensed passes, including an interception, Sunday in a loss to the Titans.
#4 C
Ethan Pocic: Placed on injured reserve
Dec 9th
The Browns placed Pocic (Achilles) on injured reserve Tuesday.
#5 RB
Jerome Ford: Sent to IR
Dec 9th
The Browns placed Ford on injured reserve Tuesday due to a shoulder injury.
#2 DT2
Mike Hall: Good to go Week 14
Dec 7th
Hall (knee) is active for Sunday's game against the Titans.
#2 RDE
Isaiah McGuire: Cleared to play vs. Tennessee
Dec 7th
McGuire (knee) is active for Sunday's game against the Titans.
#3 QB
Deshaun Watson: Unlikely to play this season
Dec 6th
Watson (Achilles) isn't expected to play at any point this season, but Cleveland plans to keep the veteran quarterback on its roster in 2026, Adam Schefter of ESPN reports.
#1 LDE
Alex Wright: Good to go
Dec 5th
Wright (quadriceps) doesn't have an injury designation for Sunday's game against the Titans, Chris Easterling of the Akron Beacon Journal reports.
#2 LDT
Sam Kamara: Signed to active roster
Dec 3rd
Kamara was signed to the Browns active roster Tuesday.
#3 LDT
Maliek Collins: Moved to IR
Dec 2nd
The Browns placed Collins (quadriceps) on the injured reserve Tuesday.