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Seahawks vs 49ers Odds, Lines, Spreads & Totals 2025

49ers
23.5 Pts
Seahawks
22.0 Pts
Sunday September 7, 2025 at 4:05 PM ET
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SF
49ers Injury Report
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SEA
Seahawks Injury Report
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SF
49ers Lineup
Inactives
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SEA
Seahawks Lineup
Inactives
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SF
49ers News
#4 RDE
Tarron Jackson: Back with team
Jul 29th
Jackson (undisclosed) was discharged from the hospital and returned to the 49ers on Monday, Matt Maiocco of NBC Sports Bay Area reports.
#6 WR
Jordan Watkins: Could be third or fourth WR?
Jul 28th
Watkins is in the mix to be third or fourth on San Francisco's WR depth chart to start the season, according to Matt Barrows of The Athletic.
#2 RCB
Eli Apple: Signs with San Francisco
Jul 27th
Apple and the 49ers agreed on a one-year contract Sunday, Adam Schefter of ESPN reports.
#1 WLB
Dee Winters: Competing for starting role in camp
Jul 27th
Winters drew praise from a star teammate at the start of training camp as the linebacker prepares to compete for a starting role in 2025, Vic Tafur of The Athletic reports.
#5 WR
Jacob Cowing: Hopeful to return in 2-3 weeks
Jul 27th
San Francisco coach Kyle Shanahan said Sunday that he's hopeful Cowing (hamstring) will be back by the week of Aug. 11 for joint practices with the Raiders, David Lombardi of SFStandard.com reports.
#1 RCB
Renardo Green: Will be out several weeks
Jul 27th
Green (hamstring) is expected to be sidelined for the next several weeks, David Lombardi of SFStandard.com reports.
#2 WR
Jauan Jennings: Leaves practice with inury
Jul 27th
Jennings left practice Sunday due to a calf injury, Nick Wagoner of ESPN.com reports.
#3 WR
Ricky Pearsall: Activated from PUP list
Jul 27th
The 49ers activated Pearsall (hamstring) from the active/PUP list Sunday.
#1 K
Jake Moody: Facing competition for job
Jul 23rd
Moody is competing with Greg Joseph for San Francisco's placekicker job, David Lombardi of SFStandard.com reports.
#1 LG
Ben Bartch: Dealing with quadriceps injury
Jul 22nd
Bartch is dealing with a quadriceps injury, Eric Branch of the San Francisco Chronicle reports.
#1 RB
Christian McCaffrey: Looking healthy at start of camp
Jul 22nd
Coach Kyle Shanahan said Tuesday that McCaffrey is "here and healthy" for the start of 49ers training camp, but the running back's workload will be managed in advance of the regular season, Nick Wagoner of ESPN.com reports.
#7 WR
Equanimeous St. Brown: Latches on with San Francisco
Jul 22nd
The 49ers signed St. Brown on Tuesday, Eric Branch of the San Francisco Chronicle reports.
#3 SLB
Curtis Robinson: Not healthy to open camp
Jul 18th
Robinson (undisclosed) was placed on the active/PUP list Friday.
#2 LDE
Yetur Gross-Matos: Sidelined to begin training camp
Jul 18th
Gross-Matos (undisclosed) was placed on the active/PUP list Friday.
#2 LT
Andre Dillard: Lands on PUP
Jul 18th
Dillard (undisclosed) was placed on the active/PUP list Friday.
#1 FS
Malik Mustapha: On PUP to begin camp
Jul 18th
Mustapha (knee) was placed on the active/PUP list by the 49ers on Friday.
#1 WR
Brandon Aiyuk: Moved to active/PUP list Friday
Jul 18th
Aiyuk (knee) was placed on the active/PUP list by the 49ers on Friday.
#3 QB
Kurtis Rourke: Begins camp on NFI
Jul 16th
The 49ers placed Rourke (knee) on the active/non-football injury list Wednesday, Matt Barrows of The Athletic reports.
SEA
Seahawks News
#3 RB
Damien Martinez: Seeking No. 3 role
Jul 29th
Martinez is competing for the No. 3 running back role after Kenny McIntosh suffered a torn ACL on Monday, Michael-Shawn Dugar of The Athletic reports.
#6 RB
D.K. Kaufman: Catches on with Seattle
Jul 28th
The Seahawks signed Kaufman to a contract Monday, Curtis Crabtree of Fox 13 Seattle reports.
#7 RB
Kenny McIntosh: Placed on IR
Jul 28th
The Seahawks placed McIntosh (knee) on injured reserve Monday, Curtis Crabtree of Fox 13 Seattle reports.
#2 TE
Elijah Arroyo: Competing with AJ Barner
Jul 28th
Arroyo is thriving as a pass catcher early in training camp, but AJ Barner's blocking makes him the favorite to replace Noah Fant as Seattle's starting tight end, according to Gregg Bell of The Tacoma News Tribune.
#2 RB
Zach Charbonnet: Sharing backfield with Walker again
Jul 24th
Charbonnet and Kenneth Walker give Seattle backfield continuity in an otherwise revamped offense, ESPN.com's Brady Henderson reports.
#1 FB
Robbie Ouzts: Runs with first-team offense
Jul 23rd
Ouzts worked with the first-team offense during the Seahawks' first day of training camp Wednesday, Gregg Bell of The News Tribune reports.
#2 RCB
Shaquill Griffin: Sidelined by illness
Jul 23rd
Griffin did not practice Wednesday due to an illness, Michael-Shawn Dugar of The Athletic reports.
#2 SLB
Uchenna Nwosu: Not close to returning
Jul 23rd
Nwosu (knee) is not expected to be ready to practice anytime soon, Brady Henderson of ESPN.com reports.
#2 NT
Johnathan Hankins: Dealing with back injury
Jul 23rd
The Seahawks placed Hankins (back) on the active/non-football injury list Wednesday, Aaron Wilson of KPRC 2 Houston reports.
#1 RB
Kenneth Walker: Back to 100 percent
Jul 23rd
Coach Mike Macdonald said Wednesday that Walker (ankle) was a full practice participant to begin training camp, Brady Henderson of ESPN.com reports. "He looks great. He's in a great spot mentally," Macdonald added. "Awesome to see him do all the things we want him to do from the get-go. I know he's really excited about what's going on. Great first day with Ken."
#1 QB
Sam Darnold: Starting QB heading into camp
Jul 23rd
Darnold will take the first-team quarterback reps when training camp starts Wednesday, and there isn't a quarterback competition with rookie third-round pick Jalen Milroe, Brady Henderson of ESPN.com reports.
#1 TE
AJ Barner: Opportunity awaits
Jul 21st
Barner will compete with rookie Elijah Arroyo for the starting tight end job after the Seahawks released Noah Fant on Sunday, Bob Condotta of The Seattle Times reports.
#3 LCB
Isas Waxter: Activated off NFI list
Jul 16th
The Seahawks activated Waxter (undisclosed) off the active/non-football injury list Wednesday, John Boyle of the team's official site reports.
#3 LILB
D'Eryk Jackson: Activated off NFI list
Jul 16th
The Seahawks activated Jackson (undisclosed) off the active/non-football injury list Wednesday, John Boyle of the team's official site reports.
#12 WR
Montorie Foster: Activated off NFI list
Jul 16th
The Seahawks activated Foster (undisclosed) off the active/non-football injury list Tuesday, John Boyle of the team's official site reports.
#11 WR
Tyrone Broden: Activated off NFI list
Jul 16th
The Seahawks activated Broden (undisclosed) off the active/non-football injury list Wednesday, John Boyle of the team's official site reports.
#2 RDE
Rylie Mills: Placed on NFI list
Jul 15th
Mills (knee) was placed on the active/non-football injury list by the Seahawks on Tuesday, Corbin K. Smith of SI.com reports.